The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 124: Calpain-1 catalytic subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium-dependent cysteine-type endopeptidase activity GO:0004198
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
7 P07384 (/ISS) P35750 (/ISS) Q27970 (/ISS) Q5NVS7 (/ISS) Q9GLG2 (/ISS) Q9GLG2 (/ISS) Q9GLG2 (/ISS)
Calcium-dependent cysteine-type endopeptidase activity GO:0004198
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
5 O35350 (/IDA) O35350 (/IDA) P07384 (/IDA) P35750 (/IDA) P97571 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
5 O35350 (/ISS) O35350 (/ISS) P35750 (/ISS) Q27970 (/ISS) Q5NVS7 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O35350 (/IPI) O35350 (/IPI) P07384 (/IPI) P97571 (/IPI)
Calcium-dependent cysteine-type endopeptidase activity GO:0004198
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
3 O35350 (/TAS) O35350 (/TAS) P07384 (/TAS)
Calcium-dependent cysteine-type endopeptidase activity GO:0004198
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2 O35350 (/ISO) O35350 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P07384 (/IDA) P97571 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 O35350 (/ISO) O35350 (/ISO)
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
2 O35350 (/ISO) O35350 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 O35350 (/ISO) O35350 (/ISO)
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
1 P97571 (/IDA)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P97571 (/IPI)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
9 O35350 (/ISS) O35350 (/ISS) P07384 (/ISS) P35750 (/ISS) Q27970 (/ISS) Q5NVS7 (/ISS) Q9GLG2 (/ISS) Q9GLG2 (/ISS) Q9GLG2 (/ISS)
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
6 O35350 (/ISS) O35350 (/ISS) P35750 (/ISS) P97571 (/ISS) Q27970 (/ISS) Q5NVS7 (/ISS)
Self proteolysis GO:0097264
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
6 O35350 (/ISS) O35350 (/ISS) P35750 (/ISS) P97571 (/ISS) Q27970 (/ISS) Q5NVS7 (/ISS)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
3 P07384 (/IDA) P35750 (/IDA) P97571 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 O35350 (/IMP) O35350 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 O35350 (/ISO) O35350 (/ISO)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 B8A6G0 (/IMP) Q7SYA9 (/IMP)
Positive regulation of cardiac muscle cell apoptotic process GO:0010666
Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
2 O35350 (/ISO) O35350 (/ISO)
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
2 O35350 (/ISO) O35350 (/ISO)
Branchiomotor neuron axon guidance GO:0021785
The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2 B8A6G0 (/IMP) Q7SYA9 (/IMP)
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
2 O35350 (/ISO) O35350 (/ISO)
Receptor catabolic process GO:0032801
The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 O35350 (/IDA) O35350 (/IDA)
Positive regulation of vascular permeability GO:0043117
Any process that increases the extent to which blood vessels can be pervaded by fluid.
2 O35350 (/ISO) O35350 (/ISO)
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
2 O35350 (/ISO) O35350 (/ISO)
Mammary gland involution GO:0060056
The tissue remodeling that removes differentiated mammary epithelia during weaning.
2 O35350 (/IMP) O35350 (/IMP)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 O35350 (/ISO) O35350 (/ISO)
Self proteolysis GO:0097264
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
2 O35350 (/ISO) O35350 (/ISO)
Negative regulation of NIK/NF-kappaB signaling GO:1901223
Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
2 O35350 (/ISO) O35350 (/ISO)
Positive regulation of leukocyte tethering or rolling GO:1903238
Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling.
2 O35350 (/ISO) O35350 (/ISO)
Response to angiotensin GO:1990776
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.
2 O35350 (/ISO) O35350 (/ISO)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P97571 (/IEP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P97571 (/IEP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P07384 (/TAS)
Positive regulation of cardiac muscle cell apoptotic process GO:0010666
Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
1 P97571 (/IMP)
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
1 P07384 (/NAS)
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
1 P97571 (/IC)
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
1 P97571 (/IDA)
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
1 P07384 (/TAS)
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
1 P97571 (/IMP)
Positive regulation of vascular permeability GO:0043117
Any process that increases the extent to which blood vessels can be pervaded by fluid.
1 P97571 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P07384 (/TAS)
Response to arsenic-containing substance GO:0046685
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
1 P97571 (/IEP)
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
1 P07384 (/IDA)
Cornification GO:0070268
A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).
1 P07384 (/TAS)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P97571 (/IMP)
Self proteolysis GO:0097264
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
1 P07384 (/IDA)
Negative regulation of NIK/NF-kappaB signaling GO:1901223
Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
1 P97571 (/IMP)
Positive regulation of leukocyte tethering or rolling GO:1903238
Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling.
1 P97571 (/IMP)
Response to angiotensin GO:1990776
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.
1 P97571 (/IMP)
Regulation of NMDA receptor activity GO:2000310
Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity.
1 P07384 (/TAS)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 O35350 (/ISS) O35350 (/ISS) P35750 (/ISS) P97571 (/ISS) Q27970 (/ISS) Q5NVS7 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 O35350 (/ISS) O35350 (/ISS) P35750 (/ISS) P97571 (/ISS) Q27970 (/ISS) Q5NVS7 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 O35350 (/IDA) O35350 (/IDA) P07384 (/IDA) P97571 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 O35350 (/IDA) O35350 (/IDA) P97571 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O35350 (/TAS) O35350 (/TAS) P07384 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O35350 (/ISO) O35350 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 O35350 (/IDA) O35350 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O35350 (/ISO) O35350 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O35350 (/ISO) O35350 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P07384 (/IDA) P97571 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 O35350 (/ISO) O35350 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P07384 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P35750 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P07384 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P07384 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 P07384 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P07384 (/HDA)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
1 P07384 (/TAS)
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