The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Barrier-to-autointegration factor, BAF
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: Barrier-to-autointegration factor B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
69 O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI)
(59 more)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
64 O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP)
(54 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
64 O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI)
(54 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
64 O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI)
(54 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
64 O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI)
(54 more)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
64 O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI) O75531 (/IPI)
(54 more)
LEM domain binding GO:0097726
Interacting selectively and non-covalently with a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF).
64 O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP) O75531 (/IMP)
(54 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 O54962 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 O54962 (/TAS)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 O54962 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 O54962 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O54962 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9R1T1 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 O54962 (/ISO)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 O54962 (/ISO)
LEM domain binding GO:0097726
Interacting selectively and non-covalently with a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF).
1 O54962 (/ISO)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Establishment of integrated proviral latency GO:0075713
A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.
65 O54962 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS)
(55 more)
Mitotic nuclear envelope reassembly GO:0007084
The cell cycle process that results in reformation of the nuclear envelope during mitotic cell division.
64 O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS)
(54 more)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
64 O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS)
(54 more)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
64 O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA)
(54 more)
Nuclear transport GO:0051169
The directed movement of substances into, out of, or within the nucleus.
64 O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS)
(54 more)
DNA integration GO:0015074
The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome.
1 O54962 (/IDA)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
1 O54962 (/ISO)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
128 A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA)
(118 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
128 A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA) A0A024R5H0 (/IDA)
(118 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
65 O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA)
(55 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
64 O75531 (/HDA) O75531 (/HDA) O75531 (/HDA) O75531 (/HDA) O75531 (/HDA) O75531 (/HDA) O75531 (/HDA) O75531 (/HDA) O75531 (/HDA) O75531 (/HDA)
(54 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
64 O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS)
(54 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
64 O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA) O75531 (/IDA)
(54 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
64 O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS) O75531 (/TAS)
(54 more)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
4 Q66KV4 (/IDA) Q66KV4 (/IDA) Q6NTS2 (/IDA) Q6NTS2 (/IDA)
Condensed chromosome GO:0000793
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
1 Q9R1T1 (/IDA)
Condensed chromosome GO:0000793
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
1 O54962 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O54962 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O54962 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O54962 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O54962 (/ISO)
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