The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tetraspanin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Tetraspanin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q8R3S2 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q8R3S2 (/ISO)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
2 A0A0B4KFQ5 (/IMP) Q9W4X6 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
2 A0A0B4KFQ5 (/IMP) Q9VGV3 (/IMP)
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
1 A0A0B4KFQ5 (/IMP)
Pore complex assembly GO:0046931
The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases.
1 Q8R3S2 (/IMP)
Protein maturation GO:0051604
Any process leading to the attainment of the full functional capacity of a protein.
1 Q8R3S2 (/IMP)
Protein maturation GO:0051604
Any process leading to the attainment of the full functional capacity of a protein.
1 Q8R3S2 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 Q8R3S2 (/IMP)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 Q8R3S2 (/ISO)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 A0A0B4KFQ5 (/ISM) Q9NB16 (/ISM) Q9U1L0 (/ISM) Q9VGV3 (/ISM) Q9W4X6 (/ISM)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 A0A0B4KFQ5 (/ISS) Q9NB16 (/ISS) Q9U1L0 (/ISS) Q9VGV3 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8R3S2 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q8R3S2 (/IDA)
Pore complex GO:0046930
Any small opening in a membrane that allows the passage of gases and/or liquids.
1 Q8R3S2 (/IMP)
Tetraspanin-enriched microdomain GO:0097197
A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities.
1 Q8R3S2 (/IDA)
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