The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Met repressor-like
".
FunFam 2: Negative modulator of initiation of replication
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA replication origin binding GO:0003688
Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
|
135 |
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
(125 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
135 |
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
(125 more) |
Double-stranded methylated DNA binding GO:0010385
Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
|
135 |
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
(125 more) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
135 |
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
P0AFY8 (/IPI)
(125 more) |
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
|
135 |
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
(125 more) |
DNA replication origin binding GO:0003688
Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
|
7 | Q9KQA4 (/ISS) Q9KQA4 (/ISS) Q9KQA4 (/ISS) Q9KQA4 (/ISS) Q9KQA4 (/ISS) Q9KQA4 (/ISS) Q9KQA4 (/ISS) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
|
135 |
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
(125 more) |
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
|
135 |
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
(125 more) |
Negative regulation of DNA-dependent DNA replication initiation GO:0032297
Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.
|
135 |
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
(125 more) |
Negative regulation of DNA-dependent DNA replication initiation GO:0032297
Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.
|
135 |
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
P0AFY8 (/IMP)
(125 more) |
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
|
135 |
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
(125 more) |
Nucleoid organization GO:0090143
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, virion, mitochondrion or chloroplast to which the DNA is confined.
|
135 |
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
P0AFY8 (/IGI)
(125 more) |
Negative regulation of DNA replication GO:0008156
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.
|
7 | Q9KQA4 (/ISS) Q9KQA4 (/ISS) Q9KQA4 (/ISS) Q9KQA4 (/ISS) Q9KQA4 (/ISS) Q9KQA4 (/ISS) Q9KQA4 (/ISS) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
135 |
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
(125 more) |
SeqA-DNA complex GO:1990097
A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle.
|
135 |
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
P0AFY8 (/IDA)
(125 more) |