The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:16-phosphogluconate dehydrogenase, decarboxylatingSC:2Mannitol-1-phosphate 5-dehydrogenase2-dehydropantoate 2-reductase2-dehydropantoate 2-reductaseMannitol-1-phosphate 5-dehydrogenase2-dehydropantoate 2-reductase2-dehydropantoate 2-reductase2-dehydropantoate 2-reductaseSC:3putative oxidoreductase GLYR1 isoform X1Glyoxylate/succinic semialdehyde reductase 22-hydroxymethylglutarate dehydrogenaseSC:4lambda-crystallin homologSC:5Ketol-acid reductoisomerase (NADP(+))Ketol-acid reductoisomeraseSC:6Glycerol-3-phosphate dehydrogenase [NAD(P)+]Glycerol-3-phosphate dehydrogenase [NAD(+)]Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicSC:73-hydroxybutyryl-CoA dehydrogenase FadB26-phosphogluconate dehydrogenase, decarboxylatingKetol-acid reductoisomerase, mitochondrialKetol-acid reductoisomerase, mitochondrial3-hydroxyisobutyrate dehydrogenase2-hydroxy-3-oxopropionate reductase3-hydroxybutyryl-CoA dehydrogenaseGlycerol-3-phosphate dehydrogenase [NAD(+)]Ketol-acid reductoisomerase, mitochondrialAltronate oxidoreductaseD-mannonate oxidoreductase, NAD-binding2-hydroxy-3-oxopropionate reductase3-sulfolactaldehyde reductaseGlycerol-3-phosphate dehydrogenaseGlycerol-3-phosphate dehydrogenase [NAD(P)+]UDP-glucose 6-dehydrogenaseL-carnitine dehydrogenaseMannitol 2-dehydrogenase6-phosphogluconate dehydrogenase (Decarboxylating)Ketol-acid reductoisomerase (NADP(+))Glycerol-3-phosphate dehydrogenase (NAD(P)(+))PAM1p protein2-dehydropantoate 2-reductase2-dehydropantoate 2-reductaseGlycerol-3-phosphate dehydrogenase [NAD(P)+]Probable 2-dehydropantoate 2-reductaseBlast:Putative oxidoreductase GLYR1 homolog6-phosphogluconate dehydrogenase, decarboxylating2-dehydropantoate 2-reductaseMannitol-1-phosphate 5-dehydrogenasePutative 3-hydroxyisobutyrate dehydrogenaseKetose-bisphosphate aldolase class-II family proteinKetose-bisphosphate aldolase class-II family protein2-dehydropantoate 2-reductasePutative 2-hydroxy-3-oxopropionate reductaseRelated to 2-dehydropantoate 2-reductaseProbable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrialGlycerol-3-phosphate dehydrogenase (NAD(+))Mitochondrial translational activator3-hydroxyacyl-CoA dehydrogenaseAltronate oxidoreductase3-hydroxyisobutyrate dehydrogenase a2-dehydropantoate 2-reductaseGlycerol-3-phosphate dehydrogenase [NAD(P)+]2-dehydropantoate 2-reductase2-dehydropantoate 2-reductase3-hydroxyacyl-CoA dehydrogenaseGlycerol-3-phosphate dehydrogenase [NAD(+)]D-mannonate oxidoreductase2-dehydropantoate 2-reductaseUncharacterized protein3-hydroxyisobutyrate dehydrogenase2-dehydropantoate 2-reductaseApbA-domain-containing protein2-dehydropantoate 2-reductase3-hydroxyisobutyrate dehydrogenase, mitochondrial, putativeApbA-domain-containing protein2-hydroxy-3-oxopropionate reductasePutative 3-hydroxyisobutyrate dehydrogenaseAltronate oxidoreductase2-dehydropantoate 2-reductase2-dehydropantoate 2-reductaseAGAP012912-PAYALI0D20438pNAD binding domain of 6-phosphogluconate dehydrogenase/NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase, putative2-dehydropantoate 2-reductaseUncharacterized proteinChromosome 1, whole genome shotgun sequencePutative 2-dehydropantoate 2-reductase2-dehydropantoate 2-reductaseUncharacterized proteinKetopantoate reductase PanE/ApbA-domain-containing proteinUncharacterized protein2-dehydropantoate 2-reductaseUncharacterized protein2-dehydropantoate 2-reductase family protein, putative2-dehydropantoate 2-reductasePutative 2-dehydropantoate 2-reductaseProbable 2-dehydropantoate 2-reductaseGlyoxylate reductase 1Uncharacterized proteinGlycerol-3-phosphate dehydrogenase [NAD(+)] 1Ketol-acid reductoisomerase chloroplasticUncharacterized proteinOxidoreductase subunitKetose-bisphosphate aldolase class-II family proteinOxidoreductase subunitAaceriAGL109WpUncharacterized proteinUncharacterized proteinGlycerol-3-phosphate dehydrogenase (NAD(P)(+))Uncharacterized proteinPredicted protein3-hydroxyisobutyrate dehydrogenaseKetopantoate reductaseUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinGlycerol-3-phosphate dehydrogenase [NAD(+)]Glycerol-3-phosphate dehydrogenase [NAD(+)]Uncharacterized proteinGlycerol-3-phosphate dehydrogenase [NAD(+)]
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FunFam 23: lambda-crystallin homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
L-gulonate 3-dehydrogenase activity GO:0050104
Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH.
7 Q5RDZ2 (/ISS) Q5RDZ2 (/ISS) Q811X6 (/ISS) Q8SPX7 (/ISS) Q8SQ26 (/ISS) Q99KP3 (/ISS) Q99KP3 (/ISS)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
7 Q5RDZ2 (/ISS) Q5RDZ2 (/ISS) Q811X6 (/ISS) Q8SPX7 (/ISS) Q8SQ26 (/ISS) Q99KP3 (/ISS) Q99KP3 (/ISS)
L-gulonate 3-dehydrogenase activity GO:0050104
Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH.
6 P14755 (/IDA) Q9VXI1 (/IDA) Q9Y2S2 (/IDA) Q9Y2S2 (/IDA) Q9Y2S2 (/IDA) Q9Y2S2 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 P14755 (/IPI) Q9Y2S2 (/IPI) Q9Y2S2 (/IPI) Q9Y2S2 (/IPI) Q9Y2S2 (/IPI)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
5 P14755 (/IDA) Q9Y2S2 (/IDA) Q9Y2S2 (/IDA) Q9Y2S2 (/IDA) Q9Y2S2 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q99KP3 (/ISO) Q99KP3 (/ISO)
L-gulonate 3-dehydrogenase activity GO:0050104
Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH.
2 Q99KP3 (/ISO) Q99KP3 (/ISO)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
2 Q99KP3 (/ISO) Q99KP3 (/ISO)
L-gulonate 3-dehydrogenase activity GO:0050104
Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH.
1 Q9VXI1 (/IMP)
Showing 1 to 9 of 9 entries

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Glucuronate catabolic process to xylulose 5-phosphate GO:0019640
The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate.
4 Q9Y2S2 (/TAS) Q9Y2S2 (/TAS) Q9Y2S2 (/TAS) Q9Y2S2 (/TAS)
Showing 1 to 1 of 1 entries

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 Q5RDZ2 (/ISS) Q5RDZ2 (/ISS) Q811X6 (/ISS) Q8SPX7 (/ISS) Q8SQ26 (/ISS) Q99KP3 (/ISS) Q99KP3 (/ISS) Q9Y2S2 (/ISS) Q9Y2S2 (/ISS) Q9Y2S2 (/ISS)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q9Y2S2 (/TAS) Q9Y2S2 (/TAS) Q9Y2S2 (/TAS) Q9Y2S2 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 Q9Y2S2 (/HDA) Q9Y2S2 (/HDA) Q9Y2S2 (/HDA) Q9Y2S2 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P14755 (/IDA)
Showing 1 to 4 of 4 entries
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