The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Arf Nucleotide-binding Site Opener,domain 2
".
FunFam 16: Exchange factor for Arf-6
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | G5EET6 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | G5EET6 (/IPI) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Microtubule depolymerization GO:0007019
The removal of tubulin heterodimers from one or both ends of a microtubule.
|
1 | G5EET6 (/IMP) |
|
Mitotic nuclear envelope disassembly GO:0007077
The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs.
|
1 | G5EET6 (/IMP) |
|
Regulation of mitotic centrosome separation GO:0046602
Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis.
|
1 | G5EET6 (/IMP) |
|
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
|
1 | G5EET6 (/IDA) |
|
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
|
1 | G5EET6 (/IMP) |
|
Negative regulation of axon extension involved in regeneration GO:0048692
Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration.
|
1 | G5EET6 (/IMP) |
|
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
|
1 | G5EET6 (/IDA) |
|
Negative regulation of mitotic spindle elongation GO:1902845
Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation.
|
1 | G5EET6 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | G5EET6 (/IDA) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | G5EET6 (/IDA) |
|
Microtubule minus-end GO:0036449
The end of a microtubule that does not preferentially grow (polymerize).
|
1 | G5EET6 (/IDA) |