The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 72: Homeobox protein Hox-B8

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
49 P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA)
(39 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
31 P13378 (/ISA) P17481 (/ISA) P17481 (/ISA) P17481 (/ISA) P17481 (/ISA) P17481 (/ISA) P17481 (/ISA) P17481 (/ISA) P17481 (/ISA) P17481 (/ISA)
(21 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
31 P13378 (/ISM) P17481 (/ISM) P17481 (/ISM) P17481 (/ISM) P17481 (/ISM) P17481 (/ISM) P17481 (/ISM) P17481 (/ISM) P17481 (/ISM) P17481 (/ISM)
(21 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
31 P13378 (/NAS) P17481 (/NAS) P17481 (/NAS) P17481 (/NAS) P17481 (/NAS) P17481 (/NAS) P17481 (/NAS) P17481 (/NAS) P17481 (/NAS) P17481 (/NAS)
(21 more)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P09632 (/IC) P09632 (/IC) P09632 (/IC) P09632 (/IC)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P09632 (/IPI) P09632 (/IPI) P09632 (/IPI) P09632 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
4 P09632 (/IMP) P09632 (/IMP) P09632 (/IMP) P09632 (/IMP)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 P13378 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 P23463 (/ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P13378 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P23463 (/ISO)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
54 P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI)
(44 more)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
54 P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP)
(44 more)
Skeletal system morphogenesis GO:0048705
The process in which the anatomical structures of the skeleton are generated and organized.
54 P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI) P09025 (/IGI)
(44 more)
Skeletal system morphogenesis GO:0048705
The process in which the anatomical structures of the skeleton are generated and organized.
54 P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP)
(44 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
53 P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA)
(43 more)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
49 P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP) P09025 (/IMP)
(39 more)
Negative regulation of myeloid cell differentiation GO:0045638
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
29 P17481 (/ISS) P17481 (/ISS) P17481 (/ISS) P17481 (/ISS) P17481 (/ISS) P17481 (/ISS) P17481 (/ISS) P17481 (/ISS) P17481 (/ISS) P17481 (/ISS)
(19 more)
Grooming behavior GO:0007625
The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.
4 P09632 (/IMP) P09632 (/IMP) P09632 (/IMP) P09632 (/IMP)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
4 P09632 (/IMP) P09632 (/IMP) P09632 (/IMP) P09632 (/IMP)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
4 P09632 (/IMP) P09632 (/IMP) P09632 (/IMP) P09632 (/IMP)
Dorsal spinal cord development GO:0021516
The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input.
4 P09632 (/IMP) P09632 (/IMP) P09632 (/IMP) P09632 (/IMP)
Negative regulation of myeloid cell differentiation GO:0045638
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
4 P09632 (/IDA) P09632 (/IDA) P09632 (/IDA) P09632 (/IDA)
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
4 P09632 (/IGI) P09632 (/IGI) P09632 (/IGI) P09632 (/IGI)
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
4 P09632 (/IMP) P09632 (/IMP) P09632 (/IMP) P09632 (/IMP)
Exocrine pancreas development GO:0031017
The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.
2 Q68EH7 (/IGI) Q68EH7 (/IGI)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
2 Q68EH7 (/IGI) Q68EH7 (/IGI)
Embryonic pectoral fin morphogenesis GO:0035118
The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.
2 Q68EH7 (/IGI) Q68EH7 (/IGI)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P23463 (/IGI)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q8AWZ0 (/IMP)
Anterior/posterior axis specification, embryo GO:0008595
The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.
1 P13378 (/NAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P13378 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P23463 (/ISO)
Posterior lateral line neuromast primordium migration GO:0048920
The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop.
1 Q8AWZ0 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
53 P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO)
(43 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
49 P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA) P09025 (/IDA)
(39 more)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
49 P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO) P09025 (/ISO)
(39 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
45 I3L3R1 (/IDA) I3L3R1 (/IDA) I3L3R1 (/IDA) I3L3R1 (/IDA) I3L3R1 (/IDA) I3L3R1 (/IDA) I3L3R1 (/IDA) I3L3R1 (/IDA) I3L3R1 (/IDA) I3L3R1 (/IDA)
(35 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P13378 (/NAS)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
1 P31273 (/IDA)