The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Iroquois-class homeobox protein IRX

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
10 P78411 (/ISA) P78412 (/ISA) P78413 (/ISA) P78414 (/ISA) P78414 (/ISA) P78415 (/ISA) Q8IYA7 (/ISA) Q8IYA7 (/ISA) Q8IYA7 (/ISA) Q9BZI1 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
10 P78411 (/ISM) P78412 (/ISM) P78413 (/ISM) P78414 (/ISM) P78414 (/ISM) P78415 (/ISM) Q8IYA7 (/ISM) Q8IYA7 (/ISM) Q8IYA7 (/ISM) Q9BZI1 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 P78412 (/NAS) P78413 (/NAS) P78414 (/NAS) P78414 (/NAS) P78415 (/NAS) Q9BZI1 (/NAS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 M9PI45 (/IDA) O01667 (/IDA) Q24248 (/IDA) Q8BIA3 (/IDA) Q9VU01 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 M9PI45 (/ISS) O01667 (/ISS) P54269 (/ISS) Q9VU01 (/ISS)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 P78414 (/IC) P78414 (/IC) Q9BZI1 (/IC)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 A5YC44 (/IDA) A5YC45 (/IDA) A9UGK1 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 A5YC44 (/IGI) A5YC45 (/IGI) A9UGK1 (/IGI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 M9PI45 (/IPI) O01667 (/IPI) Q9VU01 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 P78414 (/IDA) P78414 (/IDA) Q9BZI1 (/IDA)
Showing 1 to 10 of 21 entries

There are 146 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
9 M9PI45 (/IDA) O01667 (/IDA) P78414 (/IDA) P78414 (/IDA) Q8BIA3 (/IDA) Q9BZI1 (/IDA) Q9VU01 (/IDA) Q9YGK8 (/IDA) Q9YGK8 (/IDA)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
9 O42261 (/IMP) O42261 (/IMP) Q6DCQ1 (/IMP) Q6DCQ1 (/IMP) Q90XW5 (/IMP) Q90XW6 (/IMP) Q90XW6 (/IMP) Q9YGK8 (/IMP) Q9YGK8 (/IMP)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
9 O42261 (/IMP) O42261 (/IMP) Q6DCQ1 (/IMP) Q6DCQ1 (/IMP) Q90XW5 (/IMP) Q90XW6 (/IMP) Q90XW6 (/IMP) Q9YGK8 (/IMP) Q9YGK8 (/IMP)
Proximal/distal pattern formation GO:0009954
The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).
9 O42261 (/IMP) O42261 (/IMP) Q6DCQ1 (/IMP) Q6DCQ1 (/IMP) Q90XW5 (/IMP) Q90XW6 (/IMP) Q90XW6 (/IMP) Q9YGK8 (/IMP) Q9YGK8 (/IMP)
Retina morphogenesis in camera-type eye GO:0060042
The process in which the anatomical structure of the retina is generated and organized.
8 A0A0R4ILR3 (/IMP) A0A2R8RSU7 (/IMP) B3DKL9 (/IMP) Q5I8Y1 (/IMP) Q6P0B6 (/IMP) Q7SZP0 (/IMP) Q8JH33 (/IMP) Q90XQ7 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
7 O42261 (/IDA) O42261 (/IDA) Q6DCQ1 (/IDA) Q6DCQ1 (/IDA) Q9ER75 (/IDA) Q9YGK8 (/IDA) Q9YGK8 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
7 M9PI45 (/ISS) O01667 (/ISS) Q2TAQ8 (/ISS) Q66IK1 (/ISS) Q6F2E3 (/ISS) Q6NVN3 (/ISS) Q9VU01 (/ISS)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
6 O42261 (/IMP) O42261 (/IMP) Q6DCQ1 (/IMP) Q6DCQ1 (/IMP) Q9YGK8 (/IMP) Q9YGK8 (/IMP)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
6 O42261 (/IMP) O42261 (/IMP) Q6DCQ1 (/IMP) Q6DCQ1 (/IMP) Q9YGK8 (/IMP) Q9YGK8 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
6 O42261 (/IDA) O42261 (/IDA) Q6DCQ1 (/IDA) Q6DCQ1 (/IDA) Q9YGK8 (/IDA) Q9YGK8 (/IDA)
Showing 1 to 10 of 146 entries

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
18 B7ZRT8 (/ISS) O42261 (/ISS) O42261 (/ISS) P54269 (/ISS) Q24248 (/ISS) Q2TAQ8 (/ISS) Q4LDQ3 (/ISS) Q66IK1 (/ISS) Q688D0 (/ISS) Q6DCQ1 (/ISS)
(8 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 O42261 (/ISS) O42261 (/ISS) Q4LDQ3 (/ISS) Q6NVN3 (/ISS) Q90XW5 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q24248 (/IC) Q9YGK8 (/IC) Q9YGK8 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O42261 (/ISA) O42261 (/ISA) Q9PUR3 (/ISA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O42261 (/ISA) O42261 (/ISA) Q9PUR3 (/ISA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
3 O42261 (/ISA) O42261 (/ISA) Q9PUR3 (/ISA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P81067 (/IDA) Q93348 (/IDA)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 Q8BIA3 (/IC)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 Q9QY61 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q24248 (/HDA)
Showing 1 to 10 of 12 entries
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