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CATH Superfamily 1.10.10.60

Homeodomain-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Homeobox protein antennapediahomeobox protein Hox-B1homeobox protein Hox-C11Ultrabithorax, isoform CSex combs reducedSC:10Pyruvate carboxylase, mitochondrialSC:11HTH-type transcriptional repressor FabRHTH-type transcriptional regulator RutRTetR family transcriptional regulatorTranscriptional regulator CmeRSC:12DNA-binding protein FisDNA-binding transcriptional activator MarADNA-binding transcriptional regulator SoxSMultiple antibiotic resistance protein MarASigma-54-dependent Fis family transcriptional regulatorSC:13Zinc fingers and homeoboxes protein 2SC:14Terminase small subunitSC:15DNA-binding protein RAP1DDE-recombinase ASC:16Homeobox proteinHomeobox-containing protein 1 isoform X2insulin gene enhancer protein ISL-1TGFB-induced factor homeobox 1Homeobox and leucine zipper protein HomezSC:17Myb family transcription factorNuclear receptor corepressor 2 isoform 1Transcription factor SRM1trihelix transcription factor GT-1Homeobox expressed in ES cells 1Telomeric repeat-binding factor 2-interacting protein 1Gastrulation brain homeobox 1SC:18Ligand-dependent corepressor isoform 1major centromere autoantigen BDNA-directed RNA polymerase subunit N, putativeBrinkerDNA-invertase HinSC:19CENP-B homolog protein 1SC:2Metastasis-associated 1 family, member 3SWI/SNF complex subunit SMARCC2 isoform CCeramide synthase 5Orthodenticle homeobox 1DNA methyltransferase 1-associated protein 1cyclin-D-binding Myb-like transcription factor 1 isoform X1Transcriptional adapter 2Telomeric repeat-binding factor 2histone H2A deubiquitinase MYSM1 isoform X2DnaJ (Hsp40) homolog, subfamily C, member 2GON-4-like protein isoform X1CASP8-associated protein 2 isoform X1telomere repeats-binding bouquet formation protein 1SC:20POU domain proteinZinc finger E-box binding homeobox 1zinc fingers and homeoboxes protein 3Dek, isoform BHomeodomain-only proteinmajor centromere autoantigen BPutative phage transposaseSC:21DNA-binding protein SATBNK2 homeobox 8Zinc fingers and homeoboxes protein 1Mating-type protein ALPHA2SC:22DNA-binding transcriptional regulator NtrCSC:3MIS18 binding protein 1SC:4POU domain proteinZinc finger homeobox protein 4Homeobox protein BarH-like 2homeobox protein aristaless-like 4POU domain proteinPOU domain proteinpancreas/duodenum homeobox protein 1Zinc fingers and homeoboxes protein 3Double homeobox protein 4Homeobox protein engrailed-likeHematopoietically-expressed homeobox protein HHEXSC:5Homeobox and leucine zipper protein HomezRegulatory protein AdaSC:6LIM/homeobox protein Lhx9Paired box protein Pax-6paired box protein Pax-3 isoform X2LIM/homeobox protein Lhx3Homeotic protein bicoidHomeobox protein aristalessSC:7Zinc finger E-box binding homeobox 2SC:8Transcriptional regulator ArgR, AraC familyAraC family transcriptional regulatorTranscriptional regulator, AraC familyArabinose operon transcriptional regulatorSC:9Chromodomain-helicase-DNA-binding protein 2 isoform 1ISWI chromatin-remodeling complex ATPase ISW2MYB-related transcription factorIroquois-class homeobox protein IRXMeis2 homeobox isoform 2cTwo-component response regulatorPre-B-cell leukemia transcription factor 1transcription factor MYB1R1Transcriptional activator Myb isoform AMyb transcription factorTranscription factor RAX3Transcriptional activator Myb isoform AHomeobox A10CDC5 cell division cycle 5-likeISWI chromatin-remodeling complex ATPase CHR11 isoform Aprotein REVEILLE 6 isoform X1DNA-directed RNA polymerases I, II, and III subunitMesoderm induction early response 1, transcriptional regulatorHomeobox protein Hox-D4Zinc finger and SCAN domain-containing 20REST corepressor 3Two-component system response regulatorchromodomain-helicase-DNA-binding protein 3 isoform X1MYB transcription factorT-cell leukemia homeobox protein 3Transcriptional activator Myb isoform AHepatocyte nuclear factor 1-betachromodomain-helicase-DNA-binding protein 9 isoform X1RNA polymerase sigma-54 factorSIX homeobox 3Myb transcription factorDistal-less homeobox 2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A memberLIM homeobox 6Arginine-glutamic acid dipeptide (RE) repeatsH6 family homeobox 2One cut domain family memberHomeobox protein Hox-A5POU domain proteinShort stature homeobox 2zinc finger homeobox protein 4MYB transcription factorTrihelix transcription factor GT-2zinc fingers and homeoboxes protein 3SIX homeobox 2Visual system homeobox 1Paired mesoderm homeobox protein 1NK6 homeobox 1MYB transcription factorRetinal homeobox gene 2Homeobox protein Hox-B8Putative LIM/homeobox protein Lhx3Distal-less homeobox 1LIM/homeobox protein Lhx1Homeobox protein knotted-1-like 2MYB transcription factorNK2 homeobox 3MYB transcription factorZinc finger homeobox protein 2Empty spiracles homeobox 2Putative zinc finger homeobox protein 4BEL1-like homeodomain protein 4Homeobox protein Hox-D13SIX homeobox 5transcriptional-regulating factor 1 isoform X1Caudal type homeobox 4CDC5 cell division cycle 5-likeTrihelix transcription factor GT-2ALX homeobox protein 1Homeobox protein Hox-A3LIM homeobox transcription factor 1 betaZinc finger homeobox protein 4barH-like 2 homeobox protein-likeTranscription factor LBX1MYB transcription factorAristaless related homeoboxtrihelix transcription factor ASIL2MYB transcription factorNK2 homeobox 1Homeobox protein MOX-2Transcriptional adapterTwo-component system response regulator GlrRTyrR family transcriptional regulatorCut-like homeobox 2bBEL1-like homeodomain protein 9WUSCHEL-related homeobox 11Transcription factor GAMYBpogo transposable element with ZNF domain isoform X1Myb transcription factorHTH-type transcriptional regulator AdiYOrthopedia homeobox bdiencephalon/mesencephalon homeobox protein 1dorsal root ganglia homeobox protein-likePutative ZZ-type zinc finger-containing protein 3Homeobox protein Hox-D12Ventral anterior homeobox 2AraC family transcriptional regulatorHomeobox protein MSX-1Myb/SANT-like DNA-binding domain containing 1MYB DNA binding proteinHomeobox protein prophet of Pit-1cyclin-D-binding Myb-like transcription factor 1 isoform X2Myb transcription factorTetR family transcriptional regulatorhomeobox protein OTX2 isoform X2homeobox protein knotted-1-like 3 isoform X1homeobox-leucine zipper protein ATHB-6-likehomeobox protein Hox-A2WUSCHEL-related homeobox 4GS homeobox 2AraC family transcriptional regulatorTrihelix transcription factor ASIL2HTH-type transcriptional regulator EutRISWI chromatin-remodeling complex ATPase CHR11AraC family transcriptional regulatorMyb transcription factorMYB transcription factorHomeobox-leucine zipper protein HAT5MYB-like transcription factorArabinose operon transcriptional regulatorTwo-component system nitrogen regulation response regulator NtrXHomeobox protein engrailed-likeTelomere repeat-binding factor 1DNA-binding protein SATB1Transcriptional adapterHomeobox transcription factorbrain-specific homeobox protein homologMYB-related transcription factorMelibiose operon regulatory proteinHomeobox protein DBX1hematopoietically-expressed homeobox protein HHEXTwo component, sigma54 specific, transcriptional regulator, Fis familyHTH-type transcriptional activator RhaSPaired like homeobox 2BTranscriptional regulator, TetR familyChromodomain helicase DNA binding protein 6MYB transcription factorTranscriptional regulator, TetR familyhomeobox protein DBX2Anaerobic nitric oxide reductase transcription regulator NorRHomeobox protein engrailed-likeMelibiose operon regulatory proteinHomeobox-leucine zipper protein HAT22Zinc fingers and homeoboxes protein 3AraC family transcriptional regulatorHomeobox-leucine zipper protein REVOLUTAMYB transcription factorActivity-dependent neuroprotector homeobox bHomeobox-leucine zipper protein ATHB-13MYB proto-oncogene like 2REST corepressor 2Nanog homeobox transcription factortranscription factor MYB80Transcriptional regulator, AraC familytranscription termination factor 1 isoform X1paired mesoderm homeobox protein 2AZinc fingers and homeoboxes protein 3Psp operon transcriptional activatorhomeobox protein goosecoiddnaJ homolog subfamily C member 2 isoform X1MYB proto-oncogene like 2Transcriptional regulator, AraC familyMyb transcription factorDEK domain-containing chromatin associated proteinMYB transcription factorTranscription factor MYB36Goosecoid homeobox 2NK3 homeobox 2Paired box gene 4LIM homeobox transcription factorMyb-related protein 308Homeobox-leucine zipper protein HDG1POU domain proteinMyb transcription factorhomeobox-leucine zipper protein ATHB-13-likeDistal-less, isoform CFis family transcriptional regulatorzinc fingers and homeoboxes protein 1Aspartate/glutamate/uridylate kinase family proteinHighly divergent homeoboxZinc fingers and homeoboxes protein 1homeobox-leucine zipper protein ATHB-40Homeobox-leucine zipper protein HOX13Motor neuron and pancreas homeobox 1Highly divergent homeoboxzinc finger homeobox protein 2Gastrulation brain homeobox 2H2.0-like homeobox proteinHomeobox protein cut-likeZinc finger protein 541Retinal homeobox protein Rx-BTranscriptional regulator, AraC familytranscription repressor MYB5-likeDnaJ (Hsp40) homolog, subfamily C, member 1Even-skipped homeobox 1Zinc-finger homeodomain protein 2HTH-type transcriptional regulator ChbRMYB transcription factorFis family transcriptional regulatorZinc fingers and homeoboxes 1Putative homeodomain-like transcription factor superfamily proteinzinc fingers and homeoboxes protein 2Distal-less homeobox 4aHTH-type transcriptional regulator GadXTranscription factor MYB86Transcription factor MYB46Homeobox protein MSX-2zinc fingers and homeoboxes protein 2Homeobox-leucine zipper protein HOX24jerky protein homologTranscriptional regulator, AraC familyPre-B-cell leukemia transcription factor 1HTH-type transcriptional regulator GadWSugar-binding transcriptional regulatorjerky protein homologDNA-3-methyladenine glycosylase 2Tigger transposable element derived 5Transcription factor RAX3Two-component system sensor histidine kinase/response regulatorHomeobox proteinHomeobox transcription factorTSL-kinase interacting protein 1homeobox protein Hox-B3ALX homeobox protein 1Acetoacetate metabolism regulatory protein AtoCHomeobox-leucine zipper protein ATHB-7NK1 transcription factor-related protein 1Distal-less homeobox 4Scarecrow, isoform AAraC family transcriptional regulatorHomeobox protein cut-likeEmpty spiracles homeobox 3Myb transcription factorFormate hydrogenlyase transcriptional activatorTranscription factor TT2MYB transcription factorVisual system homeoboxAraC family transcriptional regulatorMuscle segmentation homeoboxEyegone, isoform AHTH-type transcriptional activator RhaRHTH-type transcriptional activator RhaRMYB transcription factorZinc fingers and homeoboxes 2aMix-type homeobox gene 1Small nuclear RNA-activating complex, polypeptide 4NK1 homeobox 2Transcription factor MYB15homeobox protein abdominal-Ahomeobox protein notochordMushroom body large-type Kenyon cell-specific protein 1jerky protein homolog-likeSmall nuclear RNA-activating complex, polypeptide 4Transcription factor TFIIIB component Bjerky protein homolog-likeTranscription factor MYB3R-2POU domain proteinMyb transcription factorMYB transcription factorMix paired-like homeoboxLIM homeobox transcription factor 1 alphaMotor neuron and pancreas homeobox 2bFis family transcriptional regulatorPaired mesoderm homeobox protein 2BTranscription factor MYB39Chitin synthase 8Homeobox protein Nkx-3.1Transcription factor MYB30Transcriptional adapterZinc finger homeobox 2trihelix transcription factor PTL-likeSigma-54-dependent Fis family transcriptional regulatorTranscription factor MYB44HTH-type transcriptional regulator ydeOTranscription factor MYB26Transcription factor MYB39Tigger transposable element derived 6Transcription factor GAMYBSite-specific DNA recombinaseTranscription factor WERDouble homeobox protein 4Transcription factor MYB124MYB transcription factorMotor neuron and pancreas homeobox 1Myb-related protein 305Tigger transposable element derived 6Gastrulation brain homeoboxESX homeobox 1Chitin synthase 6Kismet, isoform DPropionate catabolism operon regulatory protein PrpRHomeobox protein ceh-14Transcriptional coactivator ADA2homeobox even-skipped homolog protein 2Transcription factor MYB60Intestine specific homeoboxAraC family transcriptional regulatorMYB transcription factorHomeobox B3Blast:Brain-specific homeobox proteinArginine-glutamic acid dipeptide repeat proteinVentral anterior homeobox 1Chromodomain-helicase-DNA-binding protein 1DNA-binding E3 ubiquitin-protein ligaseNotochord homeoboxHex homeoboxTranscription factor MYB119Transcription activator snf2l1, putativebox A-binding factorTranscriptional regulatory protein TOD6Putative homeobox-leucine zipper protein ATHB-51AraC family transcriptional regulatorReplication termination factor 1Transcription factor RAX2Transcriptional regulator, AraC familyYDR026C-like proteinHomeobox transcription factorsigma-54-dependent Fis family transcriptional regulatorSmall nuclear RNA activating complex polypeptide 4MYB transcription factorGS homeobox 2NOBOX oogenesis homeoboxBlast:Homeobox protein HmxHomeobox protein lin-39Homeobox protein B-H1Orthopedia, isoform HUncharacterized protein, isoform ATranscription factor MYB113Transcription repressor MYB4Transcription factor MYB97AraC family transcriptional regulatorTetR family transcriptional regulatorMYB transcription factorSigma-54 dependent transcriptional regulatorSigma-54-dependent Fis family transcriptional regulatorHomeobox-leucine zipper protein HOX25-likeTranscription factor TRYAnomalous homeoboxMyb-like DNA-binding domain containing proteinTranscription factor RAX3Transcriptional activator MltRMyb family transcription factorEven-skipped homeobox 1Homeobox protein engrailed-likeHomeobox protein Hox-D4Uncharacterized protein, isoform ATranscriptional regulator, Fis familySlingshot protein phosphatase 1aANTP homeobox proteinHomeobox and leucine zipper encoding aNK3 homeobox 1Transcription factor MYB59Transcription factor MYB39AraC family transcriptional regulatorChromatin remodeling proteinSet3C deacetylase complex subunitSWR1-complex protein 4Reproductive homeobox 2BTranscription termination factor 1Transcription factor MYB124Intermediate neuroblasts defectivepathogenesis-related homeodomain proteinCramped chromatin regulator homolog 1NK7.1, isoform ADNA methyltransferase 1-associated protein 1Transcription factor MYB36AraC family transcriptional regulatorTranscription factor MYB96Egg-laying defective protein 27ISWI chromatin-remodeling complex ATPase ISW2LIM/homeobox protein Lhx4MYB-related transcription factorHomeobox protein notochordHomeobox protein vent1Chromatin complexes subunit BAP18Unplaced genomic scaffold supercont1.84, whole genome shotgun sequenceEven-skipped homeobox 2Transcription factor MYB1ISVch4 transposase, OrfATrihelix transcription factor GTL2Transcription factor MYB86Transcriptional regulator, TetR familyHomebox and aldo/keto reductaseSigma-54-dependent Fis family transcriptional regulatorISPsy4, transposaseRNA polymerase sigma-54 factorDNA invertaseSequence-specific DNA binding transcription factorTranscription factor TFIIIB subunitOs03g0412900 proteinDistal-less homeobox 6Homeobox protein ceh-30Trihelix transcription factor ASR3Homeobox domain proteinHTH-type transcriptional regulator AppYTranscriptional regulator, AraC familyBlast:Protein gooseberry-neuroTranscription factor MYB36MYB-related transcription factorPdc2pAraC family transcriptional regulatorHomebox and aldo/keto reductaseSi:ch73-376l24.4Hydrogenase-4 transcriptional activatorHomeobox protein TOS8Predicted proteinChromatin modification-related protein EAF1Rhox homeobox family member 1Divergent paired-related homeoboxTetR family transcriptional regulatorDnaJ-like protein subfamily C member 2Fis family transcriptional regulatorTranscription activator snf2l1, putativeImitation switch isoform alias nucleosome remodeling factor 140 kDa subunitAraC family transcriptional regulatorHomeobox protein VedSnt1pTranscription factor MYB14GL13020Uncharacterized protein, isoform BTranscription factorSiamois homeodomain 1Telomeric repeat-binding factor aUnplaced genomic scaffold supercont1.172, whole genome shotgun sequencemyb proteinMyb-like transcription factor 2Transcription factor RFX3Homeodomain-like transcriptional regulatorNK6 homeobox 1transcription factor LBX2Homeodomain transcription factor BW10aTetR family transcriptional regulatorPdc2pBacterial regulatory s, tetR family proteinChromatin-remodeling complex ATPase chainUncharacterized protein, isoform CTranscription factor MYB7Transcription factor ToyMYB-related transcription factorTwo-component system sensor histidine kinase/response regulatorHomeobox transcription factorhomeobox protein VENTXSWR1-complex protein 4HTH-type transcriptional regulatorHomeobox protein egl-5cDNA FLJ16624 fis, clone TESTI4015442, moderately similar to Mus musculus zinc finger homeodomain 4 (Zfh4-pending)TetR family transcriptional regulatorTranscriptional regulator, TetR familyZinc Finger and Homeoboxupstream activation factor subunit spp27Sigma-54-dependent transcriptional response regulator PilRTranscription factorC. Elegans HomeoboxHomeobox-leucine zipper protein ATHB-52Chromosome 1, whole genome shotgun sequenceSigma-54 dependent transcriptional regulatorSWR1-complex protein 4AraC family transcriptional regulatorAraC family transcriptional regulatorUncharacterized protein, isoform AHOP homeoboxmRNA, clone: RTFL01-36-L09Homeobox and leucine zipper encoding aCell division control protein, putativeUnplaced genomic scaffold supercont1.28, whole genome shotgun sequenceAraC family transcriptional regulatortranscription factor AS1-likePTS-dependent dihydroxyacetone kinase operon regulatory proteinMyb like transcription factorHomeobox domaincontaining proteinPredicted proteinLIM homeobox transcription factor 1 betaHomeobox protein ceh-5POU domain, class 5, transcription factor 2Homeobox domain containing protein 10SIX homeobox 9Unplaced genomic scaffold supercont2.9, whole genome shotgun sequenceTranscriptional regulator, AraC familyUnplaced genomic scaffold supercont1.71, whole genome shotgun sequenceProbable transposaseTranscription factor MYB75Myb-related protein 315Putative myb transcription factorAraC family transcriptional regulatorDNA methylation and regulatory proteinTetR family transcriptional regulatorPathogenesis-related homeodomain proteinTranscriptional adaptor ADA2, putativeTwo-component system response regulatorFis family transcriptional regulatorTranscription factor Rap1, putative (AFU_orthologue AFUA_6G07560)Homeobox protein CHOX-CAD2Transcription factor MYB30Double homeobox B-like 1Homeobox-leucine zipper protein 18Helicase/SANT-associated, DNA binding proteinHomeodomain-like transcriptional regulatorReproductive homeobox on X chromosome 11Homeobox protein six1aHTH-type transcriptional regulator VirSUncharacterized proteinUnplaced genomic scaffold supercont1.70, whole genome shotgun sequenceChromodomain-helicase-DNA-binding protein 3LIM domain familySWITCH/sucrose nonfermenting 3ATranscription factor MYB36AEL176CpCyclin-D-binding Myb transcription factor 1Transcriptional regulator, AraC/XylS familyAraC/XylS family transcriptional regulatorL-rhamnose operon transcriptional activator RhaRPre-mRNA-splicing factor CEF1Transcriptional regulator AraC/XylS familyPutative DNAj-like proteinPutative DNAj-like proteinTwo-component system sensor histidine kinase/response regulatorTwo-component system sensor histidine kinasePyruvate carboxylaseRepressor activator proteinChitin synthaseCRE-ZAG-1 proteinPyrroline-5-carboxylate reductaseResolvase TnpRDNA-binding protein SATB1Homeobox B4MmsAB operon regulatory proteinMmsAB operon regulatory proteinPROBABLE TRANSCRIPTIONAL REGULATORY PROTEINProbable transcriptional regulatory proteinUncharacterized proteinDistal-less homeobox 4BAPISPsy13, transposase OrfAFRIGIDA interacting protein 2Protein OVEREXPRESSOR OF CATIONIC PEROXIDASE 3Mechanosensory protein 3Lhx1/5 LIM homeobox proteinDNA-binding transcriptional regulatorTranscription factor MYB4Myb-related protein Myb4Transcriptional regulator, AraC/XylS familyTranscription factor LAF1-likeTranscriptional regulator AraC/XylS familyMyb-like DNA-binding domain containing protein, putativeL-rhamnose operon transcriptional activator RhaRPhotoperiod independent early flowering proteinChitin synthase 6Zinc finger protein 1TCP pilus virulence regulatory protein ToxTTranscriptional regulator, AraC/XylS family3-methyladenine DNA glycosylaseProtein CHROMATIN REMODELING 4Bric-a-bracSigma-54-dependent Fis family transcriptional regulatorV-myb avian myeloblastosis viral oncogene homolog-like 2bPutative Myb-like transcription factormyb proteinMYB transcription factorTranscription factor MYB14 isoform AMYB transcription factorOs07g0634900 proteinSensor histidine kinase TodSOne cut domain family memberGD18444C. Elegans HomeoboxVentral homeoboxAraC family transcriptional regulatorOs01g0308000 proteinGARP-like protein 2Homeobox transcription factorMyb family DNA-binding domain containing proteinAraC family transcriptional regulatorUncharacterized proteinHomeobox and leucine zipper encoding aMyb domain protein 4r1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5Transcription repressor MYB5Transcriptional regulator, AraC/XylS familyGD19964Myb-related protein 306Myb domain protein 101HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing proteinAraC family transcriptional regulatorAdenosinetriphosphataseHelicase, putativeHelicase putativeProtein CHROMATIN REMODELING 5Ribonuclease JTwo-component system sensor histidine kinase3-methyladenine DNA glycosylaseProbable transcriptional regulatorPhosphoglycerate transport system transcriptional regulatory protein PgtASigma-54 dependent response regulatorC. Elegans HomeoboxCone-rod homeobox, opposite strandNifA/NtrC family transcriptional regulatorPredicted proteinMuscle wasted, isoform DHomeodomain-like superfamily proteinEarthbound 2, isoform AOs01g0127450 proteinMiddle operon regulatorHomeobox transcription factor (RfeB)AraC family transcriptional regulatorTranscriptional regulator, AraC/XylS familyAraC family transcriptional regulatorAraC family transcriptional regulatorReproductive homeobox 3ATranscription factor MYB10MYB transcription factor MYB48Myb-related protein 306Myb transcription factorAnthocyanin regulatory C1 proteinMYB transcription factor 84Transcriptional regulator, AraC/XylS familyTetR family transcriptional regulatorSWIB complex BAF60b domain-containing proteinPutative SNF2 family helicaseSigma-54 activator protein ActBNK2bDlxUncharacterized proteinGG10235Paired box 7aHomeobox protein HAT3.1V-myb avian myeloblastosis viral oncogene homolog-like 2aGon4-like family proteinSigma-54 dependent transcriptional regulatorOne cut domain family memberPutative acetoin operon transcriptional activatorSigma-54-dependent Fis family transcriptional regulatorHomeobox protein orthopedia-like ProteinNK1 homeobox 2Homeobox protein pal-1Vent homeobox 2Homeobox protein vex1C. Elegans HomeoboxOocyte-specific homeobox 3C. Elegans HomeoboxTranscription factor proteinMsx-type homeobox proteinhomeobox protein slouNkx1-1Homeobox protein ceh-8NANOG neighbor homeoboxHomeobox protein Rhox5Putative transcription factor gt-2Protein CBR-CEH-1Homeobox protein DBX1MYB-like 2Arginine-fifty homeoboxTranscription termination factor, RNA polymerase ITranscription factor MYB57MYB transcription factorUncharacterized protein, isoform ANucleolar proteinTwo-component system sensor histidine kinase/response regulatorHybrid sensor histidine kinase/response regulatorTwo-component system sensor histidine kinase/response regulatorTranscriptional adapter 2ARCOR (REST CO-Repressor) homologTranscription factor MYB36Uncharacterized proteinHybrid sensor histidine kinase/response regulatorHybrid sensor histidine kinase/response regulatorMu phage middle operon regulator MorHomeobox protein Hox-B8Zinc finger homeobox 2Homeobox protein NANOGMuscle segment homeobox 2aHomeobox protein dsc-1Ladybird homeobox 2AraC family transcriptional regulatorHomeobox protein Hox-C3aExtraembryonic, spermatogenesis, homeobox 1Homeobox and leucine zipper encoding aTwo-component system sensor histidine kinase/response regulator, hybrid (One-component system)Two-component system sensor histidine kinase/response regulatorTelomeric repeat-binding factor 2-interacting protein 1NK3 homeobox 3Zinc fingers and homeoboxes 3Notochord homeoboxMIS18-binding protein 1Homeotic protein caudalDharmaCHD gene family protein containing chromodomain, helicase domain, and DNA-binding domainChromatin remodeling factor CHD3 (PICKLE)
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FunFam 134: Homeobox protein MSX-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
 14 A1YF16 (/ISS) A1YF16 (/ISS) A1YF16 (/ISS) A1YG93 (/ISS) A1YG93 (/ISS) A1YG93 (/ISS) A2T764 (/ISS) P35548 (/ISS) P35548 (/ISS) P35548 (/ISS)
(4 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
 7 P28360 (/ISA) P28360 (/ISA) P28360 (/ISA) P28360 (/ISA) P35548 (/ISA) P35548 (/ISA) P35548 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
 7 P28360 (/ISM) P28360 (/ISM) P28360 (/ISM) P28360 (/ISM) P35548 (/ISM) P35548 (/ISM) P35548 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
 7 P28360 (/NAS) P28360 (/NAS) P28360 (/NAS) P28360 (/NAS) P35548 (/NAS) P35548 (/NAS) P35548 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 6 P13297 (/IPI) P35548 (/IPI) P35548 (/IPI) P35548 (/IPI) Q03358 (/IPI) Q03358 (/IPI)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
 4 P28360 (/IPI) P28360 (/IPI) P28360 (/IPI) P28360 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
 4 P13297 (/IDA) P35548 (/IDA) P35548 (/IDA) P35548 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
 3 P13297 (/IMP) Q03358 (/IMP) Q03358 (/IMP)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
 3 P13297 (/IDA) Q03358 (/IDA) Q03358 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
 3 P13297 (/IMP) Q03358 (/IMP) Q03358 (/IMP)
Showing 1 to 10 of 23 entries

There are 100 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
 14 A1YF16 (/ISS) A1YF16 (/ISS) A1YF16 (/ISS) A1YG93 (/ISS) A1YG93 (/ISS) A1YG93 (/ISS) A2T764 (/ISS) P35548 (/ISS) P35548 (/ISS) P35548 (/ISS)
(4 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 14 A1YF16 (/ISS) A1YF16 (/ISS) A1YF16 (/ISS) A1YG93 (/ISS) A1YG93 (/ISS) A1YG93 (/ISS) A2T764 (/ISS) P35548 (/ISS) P35548 (/ISS) P35548 (/ISS)
(4 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
 10 A1YF16 (/ISS) A1YF16 (/ISS) A1YF16 (/ISS) P35548 (/ISS) P35548 (/ISS) P35548 (/ISS) Q0P5C3 (/ISS) Q0P5C3 (/ISS) Q0P5C3 (/ISS) Q9GK08 (/ISS)
Embryonic nail plate morphogenesis GO:0035880
The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits.
 5 P13297 (/IMP) P28360 (/IMP) P28360 (/IMP) P28360 (/IMP) P28360 (/IMP)
Odontogenesis of dentin-containing tooth GO:0042475
The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
 5 P13297 (/IMP) P28360 (/IMP) P28360 (/IMP) P28360 (/IMP) P28360 (/IMP)
Face morphogenesis GO:0060325
The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.
 5 P13297 (/IMP) P28360 (/IMP) P28360 (/IMP) P28360 (/IMP) P28360 (/IMP)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
 4 P28360 (/IDA) P28360 (/IDA) P28360 (/IDA) P28360 (/IDA)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
 4 P28360 (/IDA) P28360 (/IDA) P28360 (/IDA) P28360 (/IDA)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
 4 P13297 (/IDA) P28361 (/IDA) Q03358 (/IDA) Q03358 (/IDA)
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
 4 P28360 (/IDA) P28360 (/IDA) P28360 (/IDA) P28360 (/IDA)
Showing 1 to 10 of 100 entries

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 4 P28360 (/IDA) P28360 (/IDA) P28360 (/IDA) P28360 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
 4 P28360 (/IDA) P28360 (/IDA) P28360 (/IDA) P28360 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 3 P35548 (/IDA) P35548 (/IDA) P35548 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
 3 P35548 (/IDA) P35548 (/IDA) P35548 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
 2 Q03358 (/TAS) Q03358 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 2 Q03358 (/ISO) Q03358 (/ISO)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
 2 Q03358 (/ISO) Q03358 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 1 P13297 (/IGI)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 1 P13297 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
 1 P13297 (/ISO)
Showing 1 to 10 of 10 entries
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