CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Histone-lysine N-methyltransferase, H3 lysine-79 specific

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8TEK3
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (2)

P02281
H2B11_XENLA
Xenopus laevis
Histone H2B 1.1
F5H388
F5H388_HUMAN
Homo sapiens
Polyubiquitin-C

PDB Structure

PDB 6NN6
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase.
Anderson, C.J., Baird, M.R., Hsu, A., Barbour, E.H., Koyama, Y., Borgnia, M.J., McGinty, R.K.
Cell Rep
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