CATH Domain 6ic0A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2

Enzyme Information

3.1.3.46	Fructose-2,6-bisphosphate 2-phosphatase. based on mapping to UniProt Q16875 Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate. -!- The enzyme copurifies with EC 2.7.1.105 (cf. EC 3.1.3.54).
2.7.1.105	6-phosphofructo-2-kinase. based on mapping to UniProt Q16875 ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate. -!- Not identical with EC 2.7.1.11. -!- The enzyme copurifies with EC 3.1.3.46.

UniProtKB Entries (1)

F263_HUMAN

Homo sapiens

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

PDB Structure

PDB	6IC0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties. Boutard, N., Bialas, A., Sabiniarz, A., Guzik, P., Banaszak, K., Biela, A., Bien, M., Buda, A., Bugaj, B., Cieluch, E., Cierpich, A., Dudek, L., Eggenweiler, H.M., Fogt, J., Gaik, M., Gondela, A., Jakubiec, K., Jurzak, M., Kitlinska, A., Kowalczyk, P., Kujawa, M., Kwiecinska, K., Les, M., Lindemann, R., Maciuszek, M., Mikulski, M., Niedziejko, P., Obara, A., Pawlik, H., Rzymski, T., Sieprawska-Lupa, M., Sowinska, M., Szeremeta-Spisak, J., Stachowicz, A., Tomczyk, M.M., Wiklik, K., Wloszczak, L., Ziemianska, S., Zarebski, A., Brzozka, K., Nowak, M., Fabritius, C.H. Bioorg. Med. Chem. Lett.