CATH Domain 6i8sA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.497	Antithrombin; Chain I, domain 2
	3.30.497.10	Antithrombin, subunit I, domain 2

Domain Context

CATH Clusters

Superfamily	Antithrombin, subunit I, domain 2
Functional Family	Plasminogen activator inhibitor 1

Enzyme Information

UniProtKB Entries (1)

PAI1_HUMAN

Homo sapiens

Plasminogen activator inhibitor 1

PDB Structure

PDB	6I8S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1. Vousden, K.A., Lundqvist, T., Popovic, B., Naiman, B., Carruthers, A.M., Newton, P., Johnson, D.J.D., Pomowski, A., Wilkinson, T., Dufner, P., de Mendez, I., Mallinder, P.R., Murray, C., Strain, M., Connor, J., Murray, L.A., Sleeman, M.A., Lowe, D.C., Huntington, J.A., Vaughan, T.J. Sci Rep