CATH Domain 6i0cA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Acetylcholinesterase

Enzyme Information

3.1.1.8

Cholinesterase.

based on mapping to UniProt P06276

An acylcholine + H(2)O = choline + a carboxylate.

-!- Acts on a variety of choline esters and a few other compounds.

UniProtKB Entries (1)

CHLE_HUMAN

Homo sapiens

Cholinesterase

PDB Structure

PDB	6I0C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. Chalupova, K., Korabecny, J., Bartolini, M., Monti, B., Lamba, D., Caliandro, R., Pesaresi, A., Brazzolotto, X., Gastellier, A.J., Nachon, F., Pejchal, J., Jarosova, M., Hepnarova, V., Jun, D., Hrabinova, M., Dolezal, R., Zdarova Karasova, J., Mzik, M., Kristofikova, Z., Misik, J., Muckova, L., Jost, P., Soukup, O., Benkova, M., Setnicka, V., Habartova, L., Chvojkova, M., Kleteckova, L., Vales, K., Mezeiova, E., Uliassi, E., Valis, M., Nepovimova, E., Bolognesi, M.L., Kuca, K. Eur.J.Med.Chem.