CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family |
Enzyme Information
| 3.1.21.3 |
Type I site-specific deoxyribonuclease.
based on mapping to UniProt P10486
Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.
-!- Large group of enzymes that have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. -!- They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. -!- Multifunctional proteins which also catalyze the reactions of EC 2.1.1.72 and EC 2.1.1.73, with similar site specificity. -!- Formerly EC 3.1.24.1 and EC 3.1.24.2. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
|
UniProtKB Entries (1)
| P10486 |
T1R1_ECOLX
Escherichia coli
Type I restriction enzyme EcoR124II R protein
|
PDB Structure
| PDB | 6H2J |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of a novel domain of the motor subunit of the Type I restriction enzyme EcoR124 involved in complex assembly and DNA binding.
J. Biol. Chem.
|