CATH Domain 6fc8A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase Chk1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O14757

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14757

CHK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase Chk1

PDB Structure

PDB	6FC8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors. Yang, B., Vasbinder, M.M., Hird, A.W., Su, Q., Wang, H., Yu, Y., Toader, D., Lyne, P.D., Read, J.A., Breed, J., Ioannidis, S., Deng, C., Grondine, M., DeGrace, N., Whitston, D., Brassil, P., Janetka, J.W. J. Med. Chem.