CATH Domain 6fbvA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.120	RNA Polymerase Alpha Subunit; Chain A, domain 2
	2.170.120.12	DNA-directed RNA polymerase, insert domain

Domain Context

CATH Clusters

Superfamily	DNA-directed RNA polymerase, insert domain
Functional Family	DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt P9WGZ1

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P9WGI1

SIGA_MYCTU

Mycobacterium tuberculosis H37Rv

RNA polymerase sigma factor SigA

PDB Structure

PDB	6FBV
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Lin, W., Das, K., Degen, D., Mazumder, A., Duchi, D., Wang, D., Ebright, Y.W., Ebright, R.Y., Sineva, E., Gigliotti, M., Srivastava, A., Mandal, S., Jiang, Y., Liu, Y., Yin, R., Zhang, Z., Eng, E.T., Thomas, D., Donadio, S., Zhang, H., Zhang, C., Kapanidis, A.N., Ebright, R.H. Mol. Cell