1 keywords

CATH Domain 6eqsD02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1600 SIR2/SIRT2 'Small Domain'
Homologous Superfamily 3.30.1600.10 SIR2/SIRT2 'Small Domain'

Domain Context

CATH Clusters

Superfamily SIR2/SIRT2 'Small Domain'
Functional Family NAD-dependent protein deacylase sirtuin-5, mitochondrial

Enzyme Information

3.5.1.-
In linear amides.
based on mapping to UniProt Q9NXA8

UniProtKB Entries (1)

Q9NXA8
SIR5_HUMAN
Homo sapiens
NAD-dependent protein deacylase sirtuin-5, mitochondrial

PDB Structure

PDB 6EQS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.
Rajabi, N., Auth, M., Troelsen, K.R., Pannek, M., Bhatt, D.P., Fontenas, M., Hirschey, M.D., Steegborn, C., Madsen, A.S., Olsen, C.A.
Angew. Chem. Int. Ed. Engl.