CATH Classification

Domain Context

CATH Clusters

Superfamily Ras guanine-nucleotide exchange factors catalytic domain
Functional Family son of sevenless homolog 1 isoform X2

Enzyme Information

UniProtKB Entries (1)

P01116
RASK_HUMAN
Homo sapiens
GTPase KRas

PDB Structure

PDB 6EPP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig, R.C., Sautier, B., Schroeder, J., Moosmayer, D., Hilpmann, A., Stegmann, C.M., Werbeck, N.D., Briem, H., Boemer, U., Weiske, J., Badock, V., Mastouri, J., Petersen, K., Siemeister, G., Kahmann, J.D., Wegener, D., Bohnke, N., Eis, K., Graham, K., Wortmann, L., von Nussbaum, F., Bader, B.
Proc. Natl. Acad. Sci. U.S.A.