×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

1 keywords

CATH Domain 6elwA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.30 Glutaredoxin
Homologous Superfamily 3.40.30.10 Glutaredoxin

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Glutathione peroxidase

Enzyme Information

1.11.1.12
Phospholipid-hydroperoxide glutathione peroxidase.
based on mapping to UniProt P36969
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H(2)O.
-!- The products of action of EC 1.13.11.12 on phospholipids can act as acceptor; H(2)O(2) can also act, but much more slowly (cf. EC 1.11.1.9).

UniProtKB Entries (1)

P36969
GPX4_HUMAN
Homo sapiens
Phospholipid hydroperoxide glutathione peroxidase

PDB Structure

PDB 6ELW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction.
Borchert, A., Kalms, J., Roth, S.R., Rademacher, M., Schmidt, A., Holzhutter, H.G., Kuhn, H., Scheerer, P.
Biochim. Biophys. Acta
CATH-Gene3D is a Global Biodata Core Resource Learn more...