CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.640 | Aspartate Aminotransferase; domain 2 |
|
3.40.640.10 | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
Domain Context
CATH Clusters
| Superfamily | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
| Functional Family | Aspartate aminotransferase |
Enzyme Information
| 2.6.1.3 |
Cysteine transaminase.
based on mapping to UniProt P17174
L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
|
| 2.6.1.1 |
Aspartate transaminase.
based on mapping to UniProt P17174
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
-!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
|
UniProtKB Entries (1)
| P17174 |
AATC_HUMAN
Homo sapiens
Aspartate aminotransferase, cytoplasmic
|
PDB Structure
| PDB | 6DNB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry
|
