CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1490 | Dna Ligase; domain 1 |
|
3.30.1490.100 | DNA polymerase, Y-family, little finger domain |
Domain Context
CATH Clusters
| Superfamily | DNA polymerase, Y-family, little finger domain |
| Functional Family | DNA polymerase eta |
Enzyme Information
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt Q9Y253
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
UniProtKB Entries (1)
| Q9Y253 |
POLH_HUMAN
Homo sapiens
DNA polymerase eta
|
PDB Structure
| PDB | 6D0Z |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Sci Rep
|
