CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.110 | 4 Propeller | |
2.110.10 | Hemopexin | |
2.110.10.10 | Hemopexin-like domain |
Domain Context
CATH Clusters
Superfamily | Hemopexin-like domain |
Functional Family | Matrix metallopeptidase 24 |
Enzyme Information
3.4.24.80 |
Membrane-type matrix metalloproteinase-1.
based on mapping to UniProt P50281
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe- 342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
-!- Believed to play an important role in the activation of progelatinase A at cell surfaces. -!- Belongs to peptidase family M10.
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UniProtKB Entries (1)
P02647 |
APOA1_HUMAN
Homo sapiens
Apolipoprotein A-I
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PDB Structure
PDB | 6CLZ |
External Links | |
Method | SOLUTION NMR |
Organism | |
Primary Citation |
MT1-MMP Binds Membranes by Opposite Tips of Its beta Propeller to Position It for Pericellular Proteolysis.
Structure
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