CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.160 | Hnrnp arginine n-methyltransferase1 |
|
2.70.160.11 | Hnrnp arginine n-methyltransferase1 |
Domain Context
CATH Clusters
| Superfamily | Hnrnp arginine n-methyltransferase1 |
| Functional Family | Protein arginine N-methyltransferase 5 |
Enzyme Information
| 2.1.1.320 |
Type II protein arginine methyltransferase.
based on mapping to UniProt O14744
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L- homocysteine + [protein]-N(omega),N(omega')-dimethyl-L-arginine.
-!- The enzyme catalyzes the methylation of one of the terminal guanidino nitrogen atoms in arginine residues within proteins, forming monomethylarginine, followed by the methylation of the second terminal nitrogen atom to form a symmetrical dimethylarginine. -!- The mammalian enzyme is active in both the nucleus and the cytoplasm, and plays a role in the assembly of snRNP core particles by methylating certain small nuclear ribonucleoproteins. -!- Cf. EC 2.1.1.319, EC 2.1.1.321 and EC 2.1.1.322. -!- Formerly EC 2.1.1.23, EC 2.1.1.124, EC 2.1.1.125 and EC 2.1.1.126.
|
UniProtKB Entries (1)
| Q9BQA1 |
MEP50_HUMAN
Homo sapiens
Methylosome protein 50
|
PDB Structure
| PDB | 6CKC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
ACS Med Chem Lett
|