CATH Classification

Domain Context

CATH Clusters

Superfamily Zinc/RING finger domain, C3HC4 (zinc finger)
Functional Family Histone deacetylase 6

Enzyme Information

3.5.1.98
Histone deacetylase.
based on mapping to UniProt Q9UBN7
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

Q9UBN7
HDAC6_HUMAN
Homo sapiens
Histone deacetylase 6

PDB Structure

PDB 6CEF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
Ferreira de Freitas, R., Harding, R.J., Franzoni, I., Ravichandran, M., Mann, M.K., Ouyang, H., Lautens, M., Santhakumar, V., Arrowsmith, C.H., Schapira, M.
J. Med. Chem.
CATH-Gene3D is a Global Biodata Core Resource Learn more...