CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
|
1.20.120.330 | Nucleotidyltransferases domain 2 |
Domain Context
CATH Clusters
| Superfamily | Nucleotidyltransferases domain 2 |
| Functional Family | focal adhesion kinase 1 isoform X1 |
Enzyme Information
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P34152
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (2)
| Q63155 |
DCC_RAT
Rattus norvegicus
Netrin receptor DCC
|
| P34152 |
FAK1_MOUSE
Mus musculus
Focal adhesion kinase 1
|
PDB Structure
| PDB | 6BZ3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction.
Cell Discov
|
