CATH Classification

Domain Context

CATH Clusters

Superfamily tricorn interacting facor f3 domain
Functional Family Aminopeptidase N

Enzyme Information

3.4.11.2
Membrane alanyl aminopeptidase.
based on mapping to UniProt P15145
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
-!- Is not activated by heavy metal ions. -!- Belongs to peptidase family M1. -!- Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.

UniProtKB Entries (1)

P15145
AMPN_PIG
Sus scrofa
Aminopeptidase N

PDB Structure

PDB 6BV4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Joshi, S., Chen, L., Winter, M.B., Lin, Y.L., Yang, Y., Shapovalova, M., Smith, P.M., Liu, C., Li, F., LeBeau, A.M.
Sci Rep
CATH-Gene3D is a Global Biodata Core Resource Learn more...