CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.565 | Retinoid X Receptor |
|
1.10.565.10 | Retinoid X Receptor |
Domain Context
CATH Clusters
| Superfamily | Retinoid X Receptor |
| Functional Family | Nuclear orphan receptor ROR-beta |
Enzyme Information
UniProtKB Entries (1)
| P51449 |
RORG_HUMAN
Homo sapiens
Nuclear receptor ROR-gamma
|
PDB Structure
| PDB | 6BR2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor gamma t Inverse Agonist.
J. Med. Chem.
|