CATH Domain 6bn8B01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.150	Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
	2.170.150.20	Peptide methionine sulfoxide reductase.

Domain Context

CATH Clusters

Superfamily	Peptide methionine sulfoxide reductase.
Functional Family	Cereblon, isoform CRA_c

Enzyme Information

UniProtKB Entries (1)

BRD4_HUMAN

Homo sapiens

Bromodomain-containing protein 4

PDB Structure

PDB	6BN8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Plasticity in binding confers selectivity in ligand-induced protein degradation. Nowak, R.P., DeAngelo, S.L., Buckley, D., He, Z., Donovan, K.A., An, J., Safaee, N., Jedrychowski, M.P., Ponthier, C.M., Ishoey, M., Zhang, T., Mancias, J.D., Gray, N.S., Bradner, J.E., Fischer, E.S. Nat. Chem. Biol.