CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.70 | Cathepsin B; Chain A |
|
3.90.70.10 | Cysteine proteinases |
Domain Context
CATH Clusters
| Superfamily | Cysteine proteinases |
| Functional Family | Calpain-3 |
Enzyme Information
| 3.4.22.54 |
Calpain-3.
based on mapping to UniProt P20807
Broad endopeptidase activity.
-!- Activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site. -!- Substrates include the protein itself and connectin/titin. -!- Belongs to peptidase family C2.
|
UniProtKB Entries (1)
| P20807 |
CAN3_HUMAN
Homo sapiens
Calpain-3
|
PDB Structure
| PDB | 6BJD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.
J. Biol. Chem.
|