CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.260 | Coagulation Factor XIII; Chain A, domain 2 |
|
3.90.260.10 | Transglutaminase-like |
Domain Context
CATH Clusters
| Superfamily | Transglutaminase-like |
| Functional Family | Protein-glutamine gamma-glutamyltransferase 2 |
Enzyme Information
| 2.3.2.13 |
Protein-glutamine gamma-glutamyltransferase.
based on mapping to UniProt P21980
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)- (gamma-glutamyl)-L-lysine cross-link + NH(3).
-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine cross-links.
|
UniProtKB Entries (1)
| P21980 |
TGM2_HUMAN
Homo sapiens
Protein-glutamine gamma-glutamyltransferase 2
|
PDB Structure
| PDB | 6A8P |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity.
PLoS ONE
|
