CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1840 | main proteinase (3clpro) structure, domain 3 |
|
1.10.1840.10 | main proteinase (3clpro) structure, domain 3 |
Domain Context
CATH Clusters
| Superfamily | main proteinase (3clpro) structure, domain 3 |
| Functional Family | Replicase polyprotein 1a |
Enzyme Information
| 3.4.22.69 |
SARS coronavirus main proteinase.
based on mapping to UniProt K9N638
TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.
-!- SARS coronavirus main protease is the key enzyme in SARS coronavirus replicase polyprotein processing. -!- Belongs to peptidase family C30.
|
| 3.4.22.- |
Cysteine endopeptidases.
based on mapping to UniProt K9N638
|
| 3.4.19.12 |
Ubiquitinyl hydrolase 1.
based on mapping to UniProt K9N638
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.
|
UniProtKB Entries (1)
| K9N638 |
R1A_CVEMC
Betacoronavirus England 1
Replicase polyprotein 1a
|
PDB Structure
| PDB | 5WKK |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Eur J Med Chem
|