1 keywords

CATH Domain 5vx2C01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.437 Apoptosis Regulator Bcl-x
Homologous Superfamily 1.10.437.10 Blc2-like

Domain Context

CATH Clusters

Superfamily Blc2-like
Functional Family Induced myeloid leukemia cell differentiation protein Mcl-1

Enzyme Information

UniProtKB Entries (2)

P97287
MCL1_MOUSE
Mus musculus
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Q07820
MCL1_HUMAN
Homo sapiens
Induced myeloid leukemia cell differentiation protein Mcl-1

PDB Structure

PDB 5VX2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Brouwer, J.M., Lan, P., Cowan, A.D., Bernardini, J.P., Birkinshaw, R.W., van Delft, M.F., Sleebs, B.E., Robin, A.Y., Wardak, A., Tan, I.K., Reljic, B., Lee, E.F., Fairlie, W.D., Call, M.J., Smith, B.J., Dewson, G., Lessene, G., Colman, P.M., Czabotar, P.E.
Mol. Cell