CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.730 | Isoleucyl-tRNA Synthetase; Domain 1 |
|
1.10.730.10 | Isoleucyl-tRNA Synthetase; Domain 1 |
Domain Context
CATH Clusters
| Superfamily | Isoleucyl-tRNA Synthetase; Domain 1 |
| Functional Family | Methionyl-tRNA synthetase, putative |
Enzyme Information
UniProtKB Entries (1)
| Q38C91 |
Q38C91_TRYB2
Trypanosoma brucei brucei TREU927
Methionyl-tRNA synthetase, putative
|
PDB Structure
| PDB | 5V49 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.
Bioorg. Med. Chem. Lett.
|