CATH Domain 5v37A05

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.10	Tetratricopeptide repeat domain

Domain Context

CATH Clusters

Superfamily	Tetratricopeptide repeat domain
Functional Family	Histone-lysine N-methyltransferase SMYD3

Enzyme Information

2.1.1.43

Histone-lysine N-methyltransferase.

based on mapping to UniProt Q9H7B4

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

SMYD3_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase SMYD3

PDB Structure

PDB	5V37
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. Thomenius, M.J., Totman, J., Harvey, D., Mitchell, L.H., Riera, T.V., Cosmopoulos, K., Grassian, A.R., Klaus, C., Foley, M., Admirand, E.A., Jahic, H., Majer, C., Wigle, T., Jacques, S.L., Gureasko, J., Brach, D., Lingaraj, T., West, K., Smith, S., Rioux, N., Waters, N.J., Tang, C., Raimondi, A., Munchhof, M., Mills, J.E., Ribich, S., Porter Scott, M., Kuntz, K.W., Janzen, W.P., Moyer, M., Smith, J.J., Chesworth, R., Copeland, R.A., Boriack-Sjodin, P.A. Plos One