CATH Domain 5uzjA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Rho-associated protein kinase 1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q13464

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13464

ROCK1_HUMAN

Homo sapiens

Rho-associated protein kinase 1

PDB Structure

PDB	5UZJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors. Bandarage, U.K., Cao, J., Come, J.H., Court, J.J., Gao, H., Jacobs, M.D., Marhefka, C., Nanthakumar, S., Green, J. Bioorg. Med. Chem. Lett.