CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Pyrroline-5-carboxylate reductase 1 |
Enzyme Information
| 1.5.1.2 |
Pyrroline-5-carboxylate reductase.
based on mapping to UniProt P32322
L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
-!- Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.
|
UniProtKB Entries (1)
| P32322 |
P5CR1_HUMAN
Homo sapiens
Pyrroline-5-carboxylate reductase 1, mitochondrial
|
PDB Structure
| PDB | 5UAW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1.
J. Biol. Chem.
|