CATH Domain 5u8fA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	Polycomb protein eed

Enzyme Information

UniProtKB Entries (1)

EED_HUMAN

Homo sapiens

Polycomb protein EED

PDB Structure

PDB	5U8F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Curtin, M.L., Pliushchev, M.A., Li, H.Q., Torrent, M., Dietrich, J.D., Jakob, C.G., Zhu, H., Zhao, H., Wang, Y., Ji, Z., Clark, R.F., Sarris, K.A., Selvaraju, S., Shaw, B., Algire, M.A., He, Y., Richardson, P.L., Sweis, R.F., Sun, C., Chiang, G.G., Michaelides, M.R. Bioorg. Med. Chem. Lett.