CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family | Phosphatidylcholine-sterol acyltransferase |
Enzyme Information
| 2.3.1.43 |
Phosphatidylcholine--sterol O-acyltransferase.
based on mapping to UniProt P04180
Phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester.
-!- Palmitoyl, oleoyl, and linoleoyl can be transferred; a number of sterols, including cholesterol, can act as acceptors. -!- The bacterial enzyme also catalyzes the reactions of EC 3.1.1.4 and EC 3.1.1.5.
|
UniProtKB Entries (1)
| P04180 |
LCAT_HUMAN
Homo sapiens
Phosphatidylcholine-sterol acyltransferase
|
PDB Structure
| PDB | 5TXF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I.
J. Biol. Chem.
|