CATH Domain 5thlA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.240	Tyrosyl-Transfer RNA Synthetase
	1.10.240.10	Tyrosyl-Transfer RNA Synthetase

Domain Context

CATH Clusters

Superfamily	Tyrosyl-Transfer RNA Synthetase
Functional Family	Tyrosine--tRNA ligase

Enzyme Information

6.1.1.1

Tyrosine--tRNA ligase.

based on mapping to UniProt P54577

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).

UniProtKB Entries (1)

SYYC_HUMAN

Homo sapiens

Tyrosine--tRNA ligase, cytoplasmic

PDB Structure

PDB	5THL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy. Blocquel, D., Li, S., Wei, N., Daub, H., Sajish, M., Erfurth, M.L., Kooi, G., Zhou, J., Bai, G., Schimmel, P., Jordanova, A., Yang, X.L. Nucleic Acids Res.