CATH Domain 5t9wA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.100	Cyclophilin
	2.40.100.10	Cyclophilin-like

Domain Context

CATH Clusters

Superfamily	Cyclophilin-like
Functional Family	Peptidyl-prolyl cis-trans isomerase A

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P62937

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P62937

PPIA_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase A

PDB Structure

PDB	5T9W
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A. Steadman, V.A., Pettit, S.B., Poullennec, K.G., Lazarides, L., Keats, A.J., Dean, D.K., Stanway, S.J., Austin, C.A., Sanvoisin, J.A., Watt, G.M., Fliri, H.G., Liclican, A.C., Jin, D., Wong, M.H., Leavitt, S.A., Lee, Y.J., Tian, Y., Frey, C.R., Appleby, T.C., Schmitz, U., Jansa, P., Mackman, R.L., Schultz, B.E. J. Med. Chem.