CATH Domain 5qijA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146

11-beta-hydroxysteroid dehydrogenase.

based on mapping to UniProt P50172

An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

DHI1_MOUSE

Mus musculus

Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB	5QIJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). Li, J., Kennedy, L.J., Walker, S.J., Wang, H., Li, J.J., Hong, Z., O'Connor, S.P., Ye, X.Y., Chen, S., Wu, S., Yoon, D.S., Nayeem, A., Camac, D.M., Ramamurthy, V., Morin, P.E., Sheriff, S., Wang, M., Harper, T.W., Golla, R., Seethala, R., Harrity, T., Ponticiello, R.P., Morgan, N.N., Taylor, J.R., Zebo, R., Maxwell, B., Moulin, F., Gordon, D.A., Robl, J.A. ACS Med Chem Lett