CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.428 | HIT family, subunit A |
|
3.30.428.10 | HIT-like |
Domain Context
CATH Clusters
| Superfamily | HIT-like |
| Functional Family | m7GpppX diphosphatase |
Enzyme Information
| 3.6.1.59 |
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
based on mapping to UniProt Q96C86
A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA].
-!- The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides. -!- Decapping is an important process in the control of eukaryotic mRNA degradation. -!- The enzyme functions to clear the cell of cap structure following decay of the RNA body. -!- The nematode enzyme can also decap triply methylated substrates, 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA]. -!- Formerly EC 3.6.1.30.
|
UniProtKB Entries (1)
| Q96C86 |
DCPS_HUMAN
Homo sapiens
M7GpppX diphosphatase
|
PDB Structure
| PDB | 5OSY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.
J. Am. Chem. Soc.
|