CATH Domain 5nmvK00

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.410	Factor Xa Inhibitor
	4.10.410.10	Pancreatic trypsin inhibitor Kunitz domain

Domain Context

CATH Clusters

Superfamily	Pancreatic trypsin inhibitor Kunitz domain
Functional Family	Tissue factor pathway inhibitor

Enzyme Information

UniProtKB Entries (1)

TFPI1_HUMAN

Homo sapiens

Tissue factor pathway inhibitor

PDB Structure

PDB	5NMV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Factor Xa and VIIa inhibition by tissue factor pathway inhibitor is prevented by a monoclonal antibody to its Kunitz-1 domain. Augustsson, C., Svensson, A., Kjaer, B., Chao, T.Y., Wenjuan, X., Krogh, B.O., Breinholt, J., Clausen, J.T., Hilden, I., Petersen, H.H., Petersen, L.C. J. Thromb. Haemost.