CATH Domain 5mj6B01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1730	tricorn interacting facor f3 domain

Domain Context

CATH Clusters

Superfamily	tricorn interacting facor f3 domain
Functional Family	Leucyl-cystinyl aminopeptidase

Enzyme Information

3.4.11.3

Cystinyl aminopeptidase.

based on mapping to UniProt Q9UIQ6

Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half- cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.

-!- Belongs to peptidase family M1.

UniProtKB Entries (1)

Q9UIQ6

LCAP_HUMAN

Homo sapiens

Leucyl-cystinyl aminopeptidase

PDB Structure

PDB	5MJ6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity. Mpakali, A., Saridakis, E., Harlos, K., Zhao, Y., Kokkala, P., Georgiadis, D., Giastas, P., Papakyriakou, A., Stratikos, E. J. Med. Chem.