CATH Classification

Domain Context

CATH Clusters

Superfamily Helix hairpin bin
Functional Family Tubulin beta chain

Enzyme Information

UniProtKB Entries (3)

E1BQ43
E1BQ43_CHICK
Gallus gallus
Uncharacterized protein
P63043
STMN4_RAT
Rattus norvegicus
Stathmin-4
Q6B856
TBB2B_BOVIN
Bos taurus
Tubulin beta-2B chain

PDB Structure

PDB 5M8D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Bohnacker, T., Prota, A.E., Beaufils, F., Burke, J.E., Melone, A., Inglis, A.J., Rageot, D., Sele, A.M., Cmiljanovic, V., Cmiljanovic, N., Bargsten, K., Aher, A., Akhmanova, A., Diaz, J.F., Fabbro, D., Zvelebil, M., Williams, R.L., Steinmetz, M.O., Wymann, M.P.
Nat Commun