1 keywords

CATH Domain 5ly2D01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.650 Cupin

Domain Context

CATH Clusters

Superfamily Cupin
Functional Family Lysine-specific demethylase 4A

Enzyme Information

1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt O75164

UniProtKB Entries (1)

O75164
KDM4A_HUMAN
Homo sapiens
Lysine-specific demethylase 4A

PDB Structure

PDB 5LY2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Kawamura, A., Munzel, M., Kojima, T., Yapp, C., Bhushan, B., Goto, Y., Tumber, A., Katoh, T., King, O.N., Passioura, T., Walport, L.J., Hatch, S.B., Madden, S., Muller, S., Brennan, P.E., Chowdhury, R., Hopkinson, R.J., Suga, H., Schofield, C.J.
Nat Commun