CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.11350 |
Domain Context
CATH Clusters
Superfamily | 3.40.50.11350 |
Functional Family | GDP-fucose protein O-fucosyltransferase 1 |
Enzyme Information
2.4.1.221 |
Peptide-O-fucosyltransferase.
based on mapping to UniProt Q91ZW2
Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.
-!- Involved in the biosynthesis of O-fucosylated epidermal growth factor (EGF) and thrombospondin type 1 repeats. -!- The attachment of O-linked fucose to serine or threonine occurs on EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.
|
UniProtKB Entries (1)
Q91ZW2 |
OFUT1_MOUSE
Mus musculus
GDP-fucose protein O-fucosyltransferase 1
|
PDB Structure
PDB | 5KY9 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1.
Nat. Chem. Biol.
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