1 keywords

CATH Domain 5jljB00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.30 Roll
Topology 2.30.29 PH-domain like
Homologous Superfamily 2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family Ran-specific GTPase-activating protein 1

Enzyme Information

UniProtKB Entries (2)

P62826
RAN_HUMAN
Homo sapiens
GTP-binding nuclear protein Ran
P41920
YRB1_YEAST
Saccharomyces cerevisiae S288C
Ran-specific GTPase-activating protein 1

PDB Structure

PDB 5JLJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
Hing, Z.A., Fung, H.Y., Ranganathan, P., Mitchell, S., El-Gamal, D., Woyach, J.A., Williams, K., Goettl, V.M., Smith, J., Yu, X., Meng, X., Sun, Q., Cagatay, T., Lehman, A.M., Lucas, D.M., Baloglu, E., Shacham, S., Kauffman, M.G., Byrd, J.C., Chook, Y.M., Garzon, R., Lapalombella, R.
Leukemia