CATH Domain 5j3sA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.10	Deoxyribonuclease I; Chain A
	3.60.10.10	Endonuclease/exonuclease/phosphatase

Domain Context

CATH Clusters

Superfamily	Endonuclease/exonuclease/phosphatase
Functional Family	Tyrosyl-DNA phosphodiesterase 2

Enzyme Information

3.1.4.-

Phosphoric diester hydrolases.

based on mapping to UniProt O95551

UniProtKB Entries (1)

TYDP2_HUMAN

Homo sapiens

Tyrosyl-DNA phosphodiesterase 2

PDB Structure

PDB	5J3S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Hornyak, P., Askwith, T., Walker, S., Komulainen, E., Paradowski, M., Pennicott, L.E., Bartlett, E.J., Brissett, N.C., Raoof, A., Watson, M., Jordan, A.M., Ogilvie, D.J., Ward, S.E., Atack, J.R., Pearl, L.H., Caldecott, K.W., Oliver, A.W. Biochem.J.