CATH Classification

Domain Context

CATH Clusters

Superfamily Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P06213
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06213
INSR_HUMAN
Homo sapiens
Insulin receptor

PDB Structure

PDB 5J3H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
Lawrence, C.F., Margetts, M.B., Menting, J.G., Smith, N.A., Smith, B.J., Ward, C.W., Lawrence, M.C.
J.Biol.Chem.